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Third, the relaxing environment of the sanatorium plays a role

10.1002/ange.202008868 63 WangD.WuH.YangG.QianC.GuL.WangH.et al (2020)

doi: 10.7554/eLife.56580

Given the minor contribution of the caspase-8/caspase-3 axis to eryptosis, it can be speculated that these components of cell death machinery are retained in mature erythrocytes to ensure execution of immunologically silent eryptosis, avoiding lytic and potentially highly immunogenic necroptosis